What are Best Practices for Preparing High-Potentials for Future Leadership Roles?

As global organizations flatten hierarchies in an effort to run lean, dynamic middle managers play an increasingly important role. The best companies emphasize succession planning, requiring leadership take a determined and disciplined approach to help leaders develop and rise within their organizations. As a means of investment, firms have established clear career paths and provided career development experiences for their organization’s highest potentials. High-performing organizations have narrowed their focus to foster and develop the following key competencies: Change management capabilities are the top priority for high-potentials’ professional development. They should be prepared to influence and drive performance in a dynamic environment, where the only true constant is change. A leadership mindset is equally important for middle managers looking to advance in their career. Consistently, organizations are redefining the term “leader” to apply at multiple levels, and not just at the highest level. This includes the capabilities to make tough decisions in ambiguous business environments. Communication skills play a pivotal role in managing horizontal integration in complex organizations. The need to clearly and effectively communicate both up and down in the organizations is paramount. Possessing an understanding of team dynamics should also be a high priority. The capability to lead and develop talent is also essential for maintaining momentum for the future growth

A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development

During C. elegans vulval development, the anchor cell (AC) in the somatic gonad expresses lin-3, activating the EGF receptor signaling pathway in vulval precursor cells (VPCs) and thereby inducing and patterning VPCs. Previous studies with lin-3 mutants and transgene expression have revealed that the level of LIN-3 in the AC must be precisely regulated for proper vulval development. To understand how lin-3 expression is achieved in the AC, we identified a 59 bp lin-3 enhancer sufficient to activate lin-3 transcription solely in the AC. The enhancer contains two E-box elements, and one FTZ-F1 nuclear hormone receptor (NHR) binding site that is mutated in a vulvaless mutant, lin-3(e1417). Mutagenesis studies show that both E-boxes and the NHR binding site are necessary to express lin-3 in the AC. In vitro DNA-binding studies and in vivo functional assays indicate that distinct trans-acting factors, including the E-protein/Daughterless homolog HLH-2 and unidentified nuclear hormone receptor(s), are necessary for lin-3 transcription in the AC and thus are involved in vulval development

Universality of Sea Wave Growth and Its Physical Roots

Modern day studies of wind-driven sea waves are usually focused on wind forcing rather than on the effect of resonant nonlinear wave interactions. The authors assume that these effects are dominating and propose a simple relationship between instant wave steepness and time or fetch of wave development expressed in wave periods or lengths. This law does not contain wind speed explicitly and relies upon this asymptotic theory. The validity of this law is illustrated by results of numerical simulations, in situ measurements of growing wind seas and wind wave tank experiments. The impact of the new vision of sea wave physics is discussed in the context of conventional approaches to wave modeling and forecasting.Comment: submitted to Journal of Fluid Mechanics 24-Sep-2014, 34 pages, 10 figure

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs

Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who manifested HSRs clinically, to correlate LTA results with the clinical syndrome, to correlate LTA results with the human leukocyte antigen (HLA) allele B*1502 (HLA-B*1502) positivity in a Han Chinese-Canadian population, and to determine the cytokine network in this population. HSR patients developed fever and cutaneous eruptions in the presence or absence of organ involvement within 8 weeks of exposure to carbamazepine (CBZ), phenytoin (PHY) or lamotrigine (LTG). Control patients received AEDs without presenting HSR. We investigated 10 CBZ-HSR (4 presented with Stevens-Johnson syndrome (SJS)), 24 CBZ-controls, 10 PHY-HSR (4 presented with drug-induced liver injury (DILI)), 24 PHY-controls, 6 LTG-HSR (1 SJS and 1 DILI) and 24 LTG-controls. There were 30 Han Chinese individuals (14 HSR patients and 16 controls) in our cohort. LTA toxicity greater than 12.5%±2.5% was considered positive. Differences among groups were determined by analysis of variance. In addition, we measured cytokine secretion in the patient sera between 1 month and 3 years after the event. All Han Chinese individuals and 30% of Caucasians were genotyped for HLA-B*1502.A perfect correlation (r=0.92) was observed between positive LTA and clinical diagnosis of DILI and SJS/toxic epidermal necrolysis (TEN). HLA-B*1502 positivity in Han Chinese is a predictor of CBZ-HSR and PHY-HSR. HLA-B*1502-negative Han Chinese receiving only CBZ or a combination of CBZ-PHY tolerated the drug(s) clinically, presenting negative CBZ-LTA and PHY-LTA. However, 3 patients presenting negative CBZ-LTA and PHY-LTA, as well as negative HLA-B*1502, showed positive LTG-LTA (38%, 28% and 25%, respectively), implying that they should not be prescribed LTG. Three patients had LTA positive to both PHY and CBZ, and 3 others had LTA positive to both PHY and LTG. Clinically, all six patients presented HSR to both drugs that they tested positive to (cross-reactivity). Patients were grouped based on the clinical presentation of their symptoms as only rash and fever or a triad that characterizes "true" HSR (rash, fever and DILI or SJS/TEN). Levels of pro-inflammatory cytokines were significantly higher in patient sera compared to control sera. More specifically, the highest levels of tumor necrosis factor (TNF)-α was measured in patients presenting "true" HSR, as were the apoptotic markers Fas, caspase 8 activity and M30. We concluded that LTA is sensitive for DILI and SJS/TEN regardless of drug or ethnicity. HSR prediction will prevent AED-induced morbidity. In Han Chinese, HLA-B*1502 positivity is a predictor for CBZ-HSR and PHY-HSR. Its negativity does not predict a negative LTG-HSR. There is cross-reactivity between AEDs. Additionally, T-cell cytokines and chemokines control the pathogenesis of SJS/TEN and DILI, contributing to apoptotic processes in the liver and in the skin

Umbilicity and characterization of Pansu spheres in the Heisenberg group

For $n\geq 2$ we define a notion of umbilicity for hypersurfaces in the Heisenberg group $H_{n}$. We classify umbilic hypersurfaces in some cases, and prove that Pansu spheres are the only umbilic spheres with positive constant $p$(or horizontal)-mean curvature in $H_{n}$ up to Heisenberg translations.Comment: 32 pages, 2 figures; in Crelle's journal, 201